Primaquine-loaded transdermal patch for treating malaria: design, development, and characterization

Abstract Background The goal of the current study was to create, improve, and test a transdermal patch loaded with primaquine for treatment malaria. Several ingredients were used create patch. For choosing polymers, placebo patches created. optimization polymer ratios development testing their impact on tensile strength, in vitro drug release, permeation, ex vivo permeation employed response surface methods. F5 formulation chosen as optimal based these answers data. stability examined. According findings trials acute skin irritation, no place where given showed any signs clinical abnormalities or change body weight. No erythema edema seen rabbit’s skin. Results It observed that strength films formulated Eudragit RL100 hydroxypropyl methylcellulose ( P mix ) found between 0.32 ± 0.017 0.59 0.013 kg/cm 2 , which (F1), 0.36 0.012 (F2), 0.35 0.015 (F3) ratio 1:1, 0.42 0.011 (F4), 0.49 0.010 (F5), 0.55 0.016 (F6) 1:2 0.56 0.014 (F7), 0.57 (F8), (F9) 1:3. Data fitting Peppas, Hixon–Crowell, Higuchi, Zero-order models examine optimized (F5) release kinetic mechanism. comparison done using correlation coefficient R ). had an 0.9988, greater than other models. Therefore, it clear medication released from after release. Conclusion ideal thickness, percent elongation, therapeutic prepared delivery. by RL100: HPMC K15M (1:2) into because this combination responsible significant delivery bloodstream. has notable penetration rate. Dimethyl sulfoxide enhancer, helped obtain high statistical analysis support improved formulation. is potential vehicle administration primaquine, according studies.